Custom Project
Here's what we've got for you:
aptamer generation
in silico analysis
binding analysis
Why Custom? Because Real Impact Requires Precision
Standard solutions can’t solve non-standard problems.
In the fast-moving world of molecular diagnostics, biosensing, and precision biotechnology, custom aptamer design is no longer a luxury — it’s a necessity. AptaQ was built for this: a next-generation, modular platform that transforms your biological targets into high-performing, application-ready aptamers, fully tailored to your needs.
This is not brute-force SELEX. This is data-driven design, guided by artificial intelligence, multi-head attention mechanisms, and thermodynamic modeling. We combine the speed of computation with the insight of structural biology to offer end-to-end control over the aptamer discovery process.
And it pays off — massively.
With our guided generation engine, we generate 3 billions sequences to filter up to 250,000 unique aptamers in less then 2 hours, at a cost 10,000x lower than experimental synthesis, and with a success rate increased by over 400%. Every parameter is tunable, every outcome is measurable, every decision is explainable.
Why custom? Because your project has unique constraints, unknowns, and potential. Because innovation dies in templates. And because only a custom-built molecule can offer the precision, reliability, and scalability needed to thrive in real-world conditions.
With AptaQ, you don’t adapt to the tool — the tool adapts to your biology.
And that changes everything.
Up to 1¹²
compounds per target
20K
high value human targets
2,500
lead opportunities
Aptamer Generation – Intelligent Design with AptaGen
Our custom project pipeline initiates with AptaGen, the AI-powered module of the AptaQ suite dedicated to aptamer generation. By leveraging deep learning algorithms trained on extensive datasets of validated aptamers, AptaGen designs novel sequences tailored to specific molecular targets. This approach ensures high specificity and affinity, reducing the reliance on traditional SELEX methods. Whether targeting proteins, small molecules, or complex surfaces, AptaGen delivers optimized aptamer candidates ready for further analysis. With built-in filters for sequence quality, structural complexity, and motif redundancy, it generates only high-performance candidates. Integrated within the broader AptaQ platform, AptaGen enables rapid, scalable and intelligent aptamer discovery—ideal for diagnostics, biosensing, or therapeutic targeting.
In Silico Analysis – Comprehensive Profiling with AptaStruct and AptaBind
Once new aptamers are generated, we evaluate them in silico through AptaStruct and AptaBind, two core modules of the AptaQ suite. AptaStruct predicts the aptamer’s secondary structure and evaluates its thermodynamic profile, including MFE, ensemble diversity, and stability under physiological conditions. This ensures that only well-folded, structurally viable sequences are advanced. AptaBind then models the interaction between the aptamer and its molecular target, using machine learning and docking simulations to estimate binding affinity, contact sites, and potential off-target effects. These modules work in tandem to provide a complete computational profiling of each candidate before experimental validation. With this approach, we reduce costs and development time while increasing the likelihood of success. Whether you’re building a biosensor or a targeted capture system, AptaQ’s predictive analysis helps you move forward with confidence, selecting only the aptamers with the highest probability of functional binding.
Biophysical Validation – Empirical Confirmation with AptaSim and AptaScreen
After in silico screening, selected aptamers enter our biophysical validation pipeline, led by the AptaSim and AptaScreen modules. AptaSim simulates the dynamic behavior of aptamer structures in solution, providing insights into conformational stability and structural resilience. This helps confirm that computationally promising candidates maintain integrity under experimental conditions. AptaScreen supports high-throughput filtering of candidates based on predictive scoring, helping identify the top-performing sequences for laboratory validation. Our in vitro testing includes surface plasmon resonance (SPR), fluorescence anisotropy, and circular dichroism spectroscopy to confirm real-world binding kinetics, thermodynamics, and structure. This integration of simulation and experimentation ensures that each aptamer moving forward is functionally validated and ready for your application—whether in biosensing, molecular diagnostics, or advanced capture systems. AptaQ’s validation workflow closes the loop from design to data-driven decision making, enabling faster, smarter development of custom aptamer solutions.
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